Misdiagnosis of Huntington's disease

Applying Bioinfomatics Strategies in Huntingtons Disease Research

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Misdiagnosis of Ocular Leech Infestation

Leeches are segmented worms belonging to Phylum Annelida and make up the subclass Hirudinea. Leeches have been historically used in medicine to suck blood from patients. Ocular infestation with leech is rare, moreover it is often misdiagnosed. In this report, we describe 2 patients with continuous bright ocular bleeding after swimming in a pool, and pseudo iris prolapse in a child after trauma ...

the genetic analysis of iranian patients with huntingtons disease

huntingtons disease (hd) is an autosomal dominant inherited disease characterized by involuntary movements, behavioral and personality changes, dementia and cognitive decline. although the mean age of onset is about 40 years, it varies from 5 to 79 years. therefore, at-risk individuals are never sure to have escaped the disease. hd is a member of the growing family of neurodegenerative disorder...